Sickle Cell Disease

Michael Cruz reap hook Cell Disease Cell biology BIOL 2420 A Dr. Ben Johnson November 21, 2011 Introduction: Sickle jail cell disease is an genetic disorder in which the proboscis makes reap hook- findd blushing(a) inception follow cells. The reap hook- compel refers to the ab universal crescent shape of the red smear cells; practice red line of business cells argon shaped like a disc. harmonize to the National Institutes of health (2011), sickle cell anemia, withal known as haemoglobin SS disease, is the most common jump of sickle cell disease. Hemoglobin, the corpuscle in red blood cells that carries type O to other soundbox cells, is affected by sickle cell disease because sickle cells contain abnormal haemoglobin. This atypical hemoglobin is called sickle hemoglobin, or hemoglobin S, and it distorts the shape of red blood cells, especially when undefendable to depleted oxygen levels (National affectionateness for Biotechnology In carcassation, 2010). At the molecular level, a single cornerstone change causes a mutated ?-globin, unitary of the two types of subunit that form hemoglobin (Alberts et al., 2010). This, in turn, causes a change in the aminic acid sequence of the hemoglobin protein.

The research in this newsprint will explore the version that causes sickle cell disease, the molecular mechanism of the disease, signs and symptoms, complications, epidemiology of the disease, treatment, and ethical issues come to with the treatment of sickle cell anemia. Body: Humans employ the protein hemoglobin to transport oxygen in the blood to the major organ systems of the body. A lasting change in a single ! nucleotide triggers blood cells to make hemoglobin with an ill-advised sequence of amino acids, and sickle cell anemia results from this mutation. According to Phill Jones, a doctor in physiology and pharmacology, the sickle cell hemoglobin is less soluble than normal hemoglobin and forms fibrous precipitates, which modernise the characteristic sickle shape of affected red blood cells (2008). Sickle-shaped red blood cells are fragile and...If you regard to get a proficient essay, order it on our website: OrderCustomPaper.com

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